Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia
نویسندگان
چکیده
منابع مشابه
KIR2DS3 is Associated with Protection against Acute Myeloid Leukemia
Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...
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Although complete remissions can be achieved in most patients younger than 60 years of age with untreated acute myeloid leukemia (AML), only 30-40 % of patients remain long-term survivors. Furthermore, long-term survivors represent only 10-15 % of all AML patients older than 60 years of age and <10 % of all patients with relapsed AML. The development of new treatments for AML is therefore neede...
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Acute myeloid leukemia (AML) is a biologically complex and molecularly and clinically heterogeneous disease, and its incidence is increasing as the population ages. Cytogenetic anomalies and mutation testing remain important prognostic tools for tailoring treatment after induction therapy. Despite major advances in understanding the genetic landscape of AML and its impact on the pathophysiology...
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متن کاملANoncanonical Flt3ITD/NF-kBSignalingPathwayRepresses DAPK1 in Acute Myeloid Leukemia
Purpose:Death-associated protein kinase 1 (DAPK1), a tumor suppressor, is a rate-limiting effector in an endoplasmic reticulum(ER) stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in several tumors. Amechanistic basis for epigenetic/transcriptional repressionofDAPK1was investigated in certain forms of acute myeloid leukemia (AML) with poor prognosis, which lacked ...
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ژورنال
عنوان ژورنال: Molecules
سال: 2019
ISSN: 1420-3049
DOI: 10.3390/molecules24112103